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Hypogonadism Booklet

Hypogonadism booklet

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Female

Female Hypogonadism

A chromosomal disorder in which all or part of one of the one sex chromosomes is absent – female chromosomal status 45, X rather than 46 XX.

Also known as Turner's Syndrome, Ullrich-Turner syndrome, Gonadal dysgenesis

About the Condition

Hypogonadism occurs when the ovaries or testes (gonads) do not produce enough gonadal hormones (progesterone, estrogen, and testosterone). Hypogonadism may be present from birth due to genetic factors or may develop in adult life. The ovaries or testes atrophy (shrink), so they cannot produce enough germ cells (ova or sperm). Hypogonadism affects the growth of the brain, bone, muscle, fat, body hair, and breasts.

The pituitary gland in the brain controls gonadal hormones, which determine the sex of a fetus, when a child matures into an adult, and reproductive function. Primary hypogonadism is a problem with the ovaries or testes. Secondary hypogonadism is a result of a problem with the pituitary gland.

Hypogonadism occurs more often in males than in females.

Next page: Symptoms of Hypogonadism

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Symptoms of Hypogonadism

People of any age can develop hypogonadism. If a fetus develops hypogonadism, then it may have sexual ambiguity – the genitals may not appear clearly male or female (hermaphrodite).

If your daughter developed hypogonadism in the womb, you probably will not suspect it until she fails to reach puberty. Usually it is because of Turner’s syndrome. Hypogonadism in girls causes lack of menstrual periods (amenorrhea) and sterility. Suspect Turner’s syndrome if your daughter has this appearance:

  • Very short (20 centimeters or almost 8 inches shorter than her peers)
  • No pubic or underarm hair
  • No breast development
  • Very widely-spaced eyes
  • Low-set ears
  • Webbed neck
  • Shield-shaped chest
  • Droopy eyelids

Your Turner’s syndrome daughter may complain of dry eyes and no periods. She may have dental problems, like excessive cavities and plaque. She may demonstrate poor math skills, or another learning disability, and poor spatial perception. She may have only one kidney, and heart problems with the bicuspid valve and aorta. Turner’s syndrome is also called monosomy X, gonadal dysgenesis, or Bonnevie-Ullrich syndrome.

Women with kidney failure, liver disease, or early hysterectomy experience early menopause. Although menopause from ageing is a normal and expected occurrence, it can produce discomfort in the form of hot flashes, sleep disturbances, memory problems, bladder leakage, sexual dysfunction including low libido and pain during penetrative sex, and fatty deposits around the abdomen. Menopausal discomfort can be alleviated after about two weeks of therapy with natural hormone creams.

Next page: Causes of Hypogonadism

ProFeme® 10

ProFeme 10 progesterone cream packaging

For women

ProFeme® 10% Progesterone Cream is specifically designed for use in women with declined or lowered progesterone levels.

Downloadable Resources

AndroFeme® 1

AndroFeme 1 testosterone cream packaging

For women

AndroFeme® 1% Testosterone Cream is designed for use in women with testosterone deficiency and/or low libido.

Downloadable Resources

Causes of Hypgonadism

Hypogonadism is caused by:

  • Stress
  • Trauma
  • Excessive dieting (anorexia nervosa)
  • Radiation
  • Chemotherapy
  • Sickle cell anemia
  • Environmental toxins
  • Too much prolactin, the milk-producing hormone
  • Genetic disorders, like Turner’s syndrome or XYY or XXY syndrome
  • Disruption of complex female hormone cycling
  • Street drugs, like heroin and marijuana
  • Prescription drugs, like methadone, spironolactone, and ketokonazole
  • Liver and kidney disease
  • Cancer of the gonads
  • Removal of the pituitary gland to treat a pituitary tumor, or breast or prostate cancer
  • Diabetes mellitus
  • Malnutrition
  • Cushing syndrome
  • Hemochromatosis
  • Alstrom syndrome
  • Laurence-Moon Biedl syndrome

This list does not include all causes.

Diagnosis

Tests: Amniocentesis during pregnancy. Karyotype determination.

In utero diagnosis is via Amniocentesis - confirmation via genetic karyotyping.

Secondary Considerations

Cardiovascular considerations, osteoporosis and skeletal concerns, cognitive disorders.

Next page: Treatments for Hypogonadism

ProFeme® 10

ProFeme 10 progesterone cream packaging

For women

ProFeme® 10% Progesterone Cream is specifically designed for use in women with declined or lowered progesterone levels.

Downloadable Resources

AndroFeme® 1

AndroFeme 1 testosterone cream packaging

For women

AndroFeme® 1% Testosterone Cream is designed for use in women with testosterone deficiency and/or low libido.

Downloadable Resources

Treatments for Hypogonadism

Girls who do not produce enough estrogen or progesterone are given hormone supplements, usually oral, skin patches, or injections. Estrogen must be balanced with progesterone, because taking estrogen alone leads to a dangerous build up of the lining of the uterus (endometrial hyperplasia) that can lead to cancer of the uterus.

Hypogonadal girls need estrogen based hormone replacement therapy until age 50, when they would normally experience menopause. Hormone replacement is vital to prevent bone fractures in Turner’s syndrome women.

Kallman and Turner syndrome have no cures. They are permanent genetic disorders. Hormone replacement therapy including testosterone controls symptoms.

For all other causes of hypogonadism, the doctor must treat the underlying condition, for example, diabetes, drug abuse, or sickle cell anemia. Treatment is tailored specifically to the condition, and often requires specialists.

Next page: Further Information about Hypogonadism

ProFeme® 10

ProFeme 10 progesterone cream packaging

For women

ProFeme® 10% Progesterone Cream is specifically designed for use in women with declined or lowered progesterone levels.

Downloadable Resources

AndroFeme® 1

AndroFeme 1 testosterone cream packaging

For women

AndroFeme® 1% Testosterone Cream is designed for use in women with testosterone deficiency and/or low libido.

Downloadable Resources

Download our Booklet

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Topics discussed in the Understanding Hypogonadism booklet include:

  • What is hypogonadism?
  • When does hypogonadism occur?
  • How many people have hypogonadism?
  • What causes hypogonadism?
  • What are the symptoms of hypogonadism?
  • When should I be concerned?
  • Who is most likely to have hypogonadism?
  • How can I decrease my symptoms?
  • What are my treatment options?
  • What are the pros and cons of natural hormone creams versus synthetic treatments?11
  • What is the role of progesterone in humans?
  • What is the role of testosterone in humans?

Progesterone for Women FAQ's

Testosterone for Women FAQ's

ProFeme® 10

ProFeme 10 progesterone cream packaging

For women

ProFeme® 10% Progesterone Cream is specifically designed for use in women with declined or lowered progesterone levels.

Downloadable Resources

AndroFeme® 1

AndroFeme 1 testosterone cream packaging

For women

AndroFeme® 1% Testosterone Cream is designed for use in women with testosterone deficiency and/or low libido.

Downloadable Resources

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