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Pre-Menstrual Syndrome Booklet

Pre-menstrual syndrome booklet

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Female

Premenstrual Syndrome

Premenstrual syndrome (PMS) refers to the emotional and physical symptoms that many women experience leading up to their period (menstruation).

Also known as PMS.

About the Condition

PMS affects most women of reproductive age at some stage during their lives. The age group 30 plus tend to be more severely affected, especially those women who have had children in their late twenties and beyond.

PMS is the result of reduced progesterone production post-ovulation or anovulation. Sustained failure to ovulate or produce sufficient estrogen gives rise to the symptoms of estrogen dominance and associated wide ranging symptoms.

Next page: Symptoms of Premenstrual Syndrome

ProFeme® 10

ProFeme 10 progesterone cream packaging

For women

ProFeme® 10% Progesterone Cream is specifically designed for use in women with declined or lowered progesterone levels.

Downloadable Resources

ProFeme® 3.2

ProFeme 3.2 progesterone cream packaging

For women

ProFeme® 3.2% Progesterone Cream is specifically designed for use in women with declined or lowered progesterone levels.

Downloadable Resources

Symptoms of Premenstrual Syndrome

  • Symptoms can include:
  • Emotional symptoms
    • Irritability, Anxiety, Nervous tension
    • Lower coping ability, Difficulty concentrating, Wanting to be alone
    • Lower libido
    • Reduced interest in work and social life
    • Mood swings, Depression, Aggression
  • Physical symptoms:
    • Fluid retention (swollen fingers or ankles)
    • Bloating around the abdomen
    • Breast swelling and tenderness
    • Headaches
    • Tiredness, lethargy, insomnia
    • Increase in weight
    • Constipation, Food cravings
    • Aches and pains
    • Poor coordination or clumsiness

Symptoms may gradually become more severe with time approaching menopause and may extend to extreme form of PMS called Premenstrual dysphoric disorder (PMDD).

Next page: Causes of Premenstrual Syndrome

ProFeme® 10

ProFeme 10 progesterone cream packaging

For women

ProFeme® 10% Progesterone Cream is specifically designed for use in women with declined or lowered progesterone levels.

Downloadable Resources

ProFeme® 3.2

ProFeme 3.2 progesterone cream packaging

For women

ProFeme® 3.2% Progesterone Cream is specifically designed for use in women with declined or lowered progesterone levels.

Downloadable Resources

Causes of Premenstrual Syndrome

The exact cause of PMS is still precisely unknown, but doctors believe that PMS is most likely due to:

  • Exaggerated response to rapidly fluctuating estrogen and reduced progesterone levels Some doctors speculate that contributing factors also include:
  • Loss of serotonin, a neurotransmitter that is dependent on estrogen
  • Blocking of serotonin receptors, which can be improved by taking selective serotonin reuptake inhibitors (SSRIs) to increase the amount of serotonin circulating in the bloodstream
  • Magnesium and calcium deficiency
  • Increased endorphins (natural painkillers)
  • Altered gamma-aminobutyric (GABA) system
  • Hypoprolactinemia (too little prolactin hormone in the bloodstream)

Sex hormones influence brain function, so it is not surprising that fatigue and lethargy develop when their levels decrease.

Diagnosis

Tests: S. Progesterone taken at day 21-22, S.testosterone, S. cFT, S.LH:FSH ratio, S.prolactin , S.estrogen, U.17-ketosteroids, glucose tolerance test, S.insulin.

  • Based upon evaluation of the full collective of symptoms.
  • Age, reproductive history of pregnancies, gynecology, sexual function and menstrual patterns.
  • Progesterone deficiency score chart questionnaire is useful measure to evaluate to severity.
  • Biochemistry has limited value if serum progesterone is not taken at day 21-22 of cycle when levels should be at a peak.

Secondary Considerations

Oral contraceptives severely complicate PMS because they add to the estrogen dominance. Suggest to non-hormonal OC.

Next page: Treatment/Management of Premenstrual Syndrome

ProFeme® 10

ProFeme 10 progesterone cream packaging

For women

ProFeme® 10% Progesterone Cream is specifically designed for use in women with declined or lowered progesterone levels.

Downloadable Resources

ProFeme® 3.2

ProFeme 3.2 progesterone cream packaging

For women

ProFeme® 3.2% Progesterone Cream is specifically designed for use in women with declined or lowered progesterone levels.

Downloadable Resources

Treatment/Management of Premenstrual Syndrome

Progesterone is the gold standard treatment for PMS. Progesterone is the hormone released by the ovary once ovulation has taken place. Pure progesterone, also called natural progesterone, is significantly different from synthetic pharmaceutical progestins (also called progestagens) which do not work in treating PMS.

If you are young, sexually active, and desire contraception, then your doctor may suggest a prescription for birth control pills to control your PMS. Your PMS symptoms may respond because the Pill prevents ovulation and overrides your fluctuating hormone levels. Your periods will be lighter, and you may have fewer cramps. However, the Pill is not a suitable solution if you:

  • Would like to become pregnant
  • Have migraines, high blood pressure, diabetes, heart disease, prior stroke, or a clotting disorder
  • Are older than 35
  • Are a staunch Catholic

The known side-effects of birth control pills are: Acne; nausea; headaches; bloating; breast tenderness; breakthrough bleeding between periods; decreased sexual interest (libido); benign liver tumors; and a slightly increased chance of developing breast cancer. Combination birth control pills that contain estrogen and progestin may aggravate your symptoms.

Natural progesterone injections are inefficient because they require daily top-ups due to the short half-life of progesterone. Their use is restricted to assisted fertility programs. Medroxyprogesterone acetate is a synthetic progestin injection sometimes used for severe PMS or PMDD that temporarily stops ovulation.

PMS responds best to true progesterone. Natural progesterone is best used as a topical cream or a vaginal or rectal suppository. Most PMS suffers and prescribers opt for the more easily absorbed natural progesterone cream that you can apply to your skin, which has fewer, less intense side-effects than the progestins.

Next page: Further information about Premenstrual Syndrome

ProFeme® 10

ProFeme 10 progesterone cream packaging

For women

ProFeme® 10% Progesterone Cream is specifically designed for use in women with declined or lowered progesterone levels.

Downloadable Resources

ProFeme® 3.2

ProFeme 3.2 progesterone cream packaging

For women

ProFeme® 3.2% Progesterone Cream is specifically designed for use in women with declined or lowered progesterone levels.

Downloadable Resources

Download our Booklet

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Topics discussed in the Understanding Premenstrual Syndrome booklet include:

  • What is PMS?
  • Who discovered PMS?
  • What are the signs and symptoms of PMS?
  • How many women are affected by PMS?
  • Who develops PMS?
  • What does not cause PMS?
  • Why does PMS develop?
  • How dangerous is PMS?
  • What happens during PMS?
  • When should I seek medical treatment?
  • How is PMS diagnosed?
  • How is PMS treated?

Progesterone for Women FAQ's

ProFeme® 10

ProFeme 10 progesterone cream packaging

For women

ProFeme® 10% Progesterone Cream is specifically designed for use in women with declined or lowered progesterone levels.

Downloadable Resources

ProFeme® 3.2

ProFeme 3.2 progesterone cream packaging

For women

ProFeme® 3.2% Progesterone Cream is specifically designed for use in women with declined or lowered progesterone levels.

Downloadable Resources

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